Effects of transcranial alternating current stimulation on motor performance and motor learning for healthy individuals: A systematic review and meta-analysis

作者：Kun Hu, Ruihan Wan, Ying Liu, Maolin Niu, Jianrui Guo, Feng Guo · 发表于：Frontiers in Physiology · 年份：2022 · DOI：10.3389/fphys.2022.1064584 · 被引用次数：20 · 研究领域：Transcranial Magnetic Stimulation Studies、Neural and Behavioral Psychology Studies、EEG and Brain-Computer Interfaces

Objective: Previous behavioral studies have reported the potential of transcranial alternating current stimulation in analyzing the causal relationship between neural activity and behavior. However, the efficacy of tACS on motor performance and learning in healthy individuals remains unclear. This systematic reviewexamines the effectiveness of tACS on motor performance and motor learning in healthy individuals. Methods: Literature was systematically searched through the Cochrane Library, PubMed, EMBASE, and Web of Science until 16 October 2022. Studies were eligible for review if they were randomized, parallel, or crossover experimental designs and reported the efficacy of tACS on motor performance and motor learning in healthy adults. Review Manager 5.3 was used to evaluate the methodological quality and analyze the combined effect. Results: Ten studies (270 participants) met all the inclusion criteria. The results showed that motor performance was not significantly greater than that with sham tACS stimulation [I 2 = 44%, 95% CI (–0.01, 0.35), p = 0.06, standardized mean difference = 0.17], whereas motor learning ability improved significantly [I 2 = 33%, 95% CI (−1.03, −0.31), p = 0.0002, SMD = −0.67]. Subgroup analysis found that gamma bend tACS could affect the changes in motor performance (I 2 = 6%, 95% CI (0.05, 0.51), p = 0.02, SMD = 0.28), and online tACS did as well [I 2 = 54%, 95% CI (0.12, 0.56), p = 0.002, SMD = 0.34]. Conclusion: The results showed that tACS effe...