Peripheral membrane proteins modulate stress tolerance by safeguarding cellulose synthases

作者：Christopher Kesten, Álvaro García-Moreno, Vítor Amorim‐Silva, Alexandra Menna, Araceli G. Castillo, Francisco Percio, Laia Armengot, Noemí Ruiz‐López, Yvon Jaillais, Clara Sánchez‐Rodríguez, Miguel A. Botella · 发表于：Science Advances · 年份：2022 · DOI：10.1126/sciadv.abq6971 · 被引用次数：29 · 研究领域：Polysaccharides and Plant Cell Walls、Plant nutrient uptake and metabolism、Advanced Cellulose Research Studies

Controlled primary cell wall remodeling allows plant growth under stressful conditions, but how these changes are conveyed to adjust cellulose synthesis is not understood. Here, we identify the TETRATRICOPEPTIDE THIOREDOXIN-LIKE (TTL) proteins as new members of the cellulose synthase complex (CSC) and describe their unique and hitherto unknown dynamic association with the CSC under cellulose-deficient conditions. We find that TTLs are essential for maintaining cellulose synthesis under high-salinity conditions, establishing a stress-resilient cortical microtubule array, and stabilizing CSCs at the plasma membrane. To fulfill these functions, TTLs interact with CELLULOSE SYNTHASE 1 (CESA1) and engage with cortical microtubules to promote their polymerization. We propose that TTLs function as bridges connecting stress perception with dynamic regulation of cellulose biosynthesis at the plasma membrane.