Potential effect of dietary zinc intake on telomere length: A cross-sectional study of US adults

作者：Huanchen Shi, Xiaoxuan Li, Haihong Yu, Wanting Shi, Yue Lin, Yunping Zhou · 发表于：Frontiers in Nutrition · 年份：2022 · DOI：10.3389/fnut.2022.993425 · 被引用次数：14 · 研究领域：Telomeres, Telomerase, and Senescence、Birth, Development, and Health、Nuclear Structure and Function

Background Telomere length, which is related to chronic diseases and premature mortality, is influenced by dietary factors. Zinc is known as a dietary antioxidant micronutrient, however, its impact on telomere length remains unclear. Objective We aimed to examine the potential effect of dietary zinc intake on telomere length among middle-aged and older individuals in the US. Materials and methods Our study included 3,793 US participants aged 45 years and older from the 1999 to 2002 National Health and Nutrition Examination Survey (NHANES). 24-h dietary recall interviews were employed to evaluate zinc consumption. Leukocyte telomere length was assessed by real-time quantitative polymerase chain reaction (qPCR). We adopted generalized linear models to investigate the effect of dietary zinc intake on telomere length, and subgroup analyses were further applied. We further evaluated the dose-response relationship using restricted cubic spline analysis. Results Among the 3,793 participants, the average telomere length was 0.926 ± 0.205 (T/S ratio) or 5509.5 ± 494.9 (bp). After adjusting for major confounders, every 5 mg increment in dietary zinc consumption was related to 0.64% (95% CI: 0.17%, 1.10%) longer telomere length. In the subgroup analyses, significant relationships were found in females (Percentage change: 1.11%; 95% CI: 0.48%, 1.75%), obese (Percentage change: 0.88%; 95% CI: 0.26%, 1.50%), and low energy intake individuals (Percentage change: 0.99%; 95% CI: 0.51%, 1.46%)...