Circulating Biomarkers in Hypertrophic Cardiomyopathy

作者：Eldon L. Matthia, Michael L. Setteducato, Mohammed Elzeneini, Nicholas Vernace, Michael Salerno, Christopher M. Kramer, Ellen Catherine Keeley · 发表于：Journal of the American Heart Association · 年份：2022 · DOI：10.1161/jaha.122.027618 · 被引用次数：56 · 研究领域：Cardiomyopathy and Myosin Studies、Galectins and Cancer Biology、Viral Infections and Immunology Research

Hypertrophic cardiomyopathy is the most common genetic heart disease. Biomarkers, molecules measurable in the blood, could inform the clinician by aiding in diagnosis, directing treatment, and predicting outcomes. We present an updated review of circulating biomarkers in hypertrophic cardiomyopathy representing key pathologic processes including wall stretch, myocardial necrosis, fibrosis, inflammation, hypertrophy, and endothelial dysfunction, in addition to their clinical significance.