Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina

作者：Diane Uschner, Matthew J. Bott, William H. Lagarde, Joseph Keating, Hazel Tapp, Andrea A. Berry, Austin Seals, Iqra Munawar, John S. Schieffelin, Joshua Yukich, Michele Santacatterina, Mihili Gunaratne, Lida M. Fette, Brian Burke, Greg Strylewicz, Sharon L. Edelstein, Amina Ahmed, Kristen Miller, John W. Sanders, David M. Herrington, William S. Weintraub, Michael S. Runyon · 发表于：Vaccines · 年份：2022 · DOI：10.3390/vaccines10111922 · 被引用次数：13 · 研究领域：SARS-CoV-2 and COVID-19 Research、Vaccine Coverage and Hesitancy、COVID-19 epidemiological studies

We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in the North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associated with a lower risk of breakthrough in the time-to-event analysis included older age, prior SARS-CovV-2 infection, higher rates of face mask use, and receipt of a booster vaccination. Higher rates of breakthrough were reported by participants vaccinated with BNT162b2 or Ad26.COV2.S compared to mRNA-1273, in suburban or rural counties compared to urban counties, and during circulation of the Delta and Omicron variants.