Intraparenchymal metastases as a cause for local recurrence of pancreatic cancer

作者：Ashley Kiemen, Young Geun Choi, Alicia M. Braxton, Cristina Almagro Pérez, Sarah E. Graham, Mia P. Grahn, Neha Nanda, Nicholas J. Roberts, Laura D. Wood, Pei‐Hsun Wu, Ralph H. Hruban, Denis Wirtz · 发表于：Histopathology · 年份：2022 · DOI：10.1111/his.14839 · 被引用次数：17 · 研究领域：Pancreatic and Hepatic Oncology Research、Cancer Diagnosis and Treatment、Renal cell carcinoma treatment

Using CODA, a technique for three-dimensional reconstruction of large tissues, Kiemen et al. report observation of a microscopic focus of pancreatic cancer found in the vasculature of grossly normal human pancreas tissue resected adjacent to a large tumour. They use TP53 and SMAD4 staining to relate the small focus to the primary tumour. This report describes a represents a probable case of intraparenchymal metastasis of pancreatic cancer, revealing a probable cause of local recurrence.