Reperfusion Injury Is Associated With Poor Outcome in Patients With Recanalization After Thrombectomy

作者：Ying Zhou, Yaode He, Shenqiang Yan, Lin Chen, Ruoxia Zhang, Jinjin Xu, Haitao Hu, David S. Liebeskind, Min Lou · 发表于：Stroke · 年份：2022 · DOI：10.1161/strokeaha.122.039337 · 被引用次数：103 · 研究领域：Acute Ischemic Stroke Management、Traumatic Brain Injury and Neurovascular Disturbances、Stroke Rehabilitation and Recovery

Background: The existence of cerebral reperfusion injury in human beings remains controversial. Thus, we aimed to explore the presence of reperfusion injury in acute ischemic stroke patients with recanalization after mechanical thrombectomy and analyzed its impact on neurological outcome. Methods: We reviewed our prospectively collected database CIPPIS (Comparison Influence to Prognosis of CTP and MRP in AIS Patients, NCT03367286), and enrolled anterior circulation large artery occlusion patients with recanalization after mechanical thrombectomy who underwent (1) computed tomography (CT) perfusion on admission and immediately after recanalization to determine reperfusion region, and (2) CT and/or magnetic resonance imaging (MRI) immediately and 24 hours after recanalization to determine lesion areas. The expansion of lesion between recanalization and 24 hours within reperfusion region was potentially caused by reperfusion, thus termed as radiological observed reperfusion injury (RORI). Based on the imaging modality immediately after recanalization, RORI was further divided into RORI CT and RORI MRI . We first included a small cohort who had performed both CT and MRI immediately after recanalization to validate the consistency between RORI CT and RORI MRI (Study 1). Then the association with RORI CT and poor outcome, defined as 3-month modified Rankin Scale score of 3 to 6, was explored in a larger cohort (Study 2). Results: Study 1 included 23 patients and good consistency wa...