Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinoma

作者：Jing Wang, Tie‐Jun Huang, Yan Mei, Fei‐Fei Luo, Dehuan Xie, Li‐Xia Peng, Bao-Qi Liu, Mei-Ling Fan, Jiangbo Zhang, Shutao Zheng, Chao‐Nan Qian, Bi‐Jun Huang · 发表于：Cancer Gene Therapy · 年份：2022 · DOI：10.1038/s41417-022-00554-2 · 被引用次数：11 · 研究领域：Cancer-related molecular mechanisms research、Circular RNAs in diseases、RNA modifications and cancer

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors in China. However, there are no targets to treat ESCC because the molecular mechanism behind the cancer is still unclear. Here, we found a novel long noncoding RNA LINC02820 was upregulated in ESCC and associated with the ESCC clinicopathological stage. Through a series of functional experiments, we observed that LINC02820 only promoted the migration and invasion capabilities of ESCC cell lines. Mechanically, we found that LINC02820 may affect the cytoskeletal remodeling, interact with splice factor 3B subunit 3 (SF3B3), and cooperate with TNFα to amplify the NF-κB signaling pathway, which can lead to ESCC metastasis. Overall, our findings revealed that LINC02820 is a potential biomarker and therapeutic target for the diagnosis and treatment of ESCC.