Efficacy of phage therapy in preclinical models of bacterial infection: a systematic review and meta-analysis

作者：Sergio Alejandro Gómez‐Ochoa, Melissa Pitton, Luca G. Valente, Cristian David Sosa Vesga, Jorge Largo, A. Centeno, Juliana Alexandra Hernández Vargas, Silvia Juliana Trujillo-Cáceres, Taulant Muka, David R. Cameron, Yok‐Ai Que · 发表于：The Lancet Microbe · 年份：2022 · DOI：10.1016/s2666-5247(22)00288-9 · 被引用次数：73 · 研究领域：Bacteriophages and microbial interactions、Cancer Research and Treatments、Vibrio bacteria research studies

BACKGROUND: Antimicrobial resistance of bacterial pathogens is an increasing clinical problem and alternative approaches to antibiotic chemotherapy are needed. One of these approaches is the use of lytic bacterial viruses known as phage therapy. We aimed to assess the efficacy of phage therapy in preclinical animal models of bacterial infection. METHODS: measure and its 95% CI were also calculated. This study is registered with PROSPERO, CRD42022311309. FINDINGS: = 99% [98 to 99]) treated with phage therapy had significantly lower tissue bacterial loads at 5 ± 2 days of follow-up compared with placebo. INTERPRETATION: Phage therapy significantly improved animal survival and reduced organ bacterial loads compared with placebo in preclinical animal models. However, high heterogeneity was observed in some comparisons. More evidence is needed to identify the factors influencing phage therapy performance to improve future clinical application. FUNDING: Swiss National Foundation and Swiss Heart Foundation.