Reshaping the Ventricle From Within

作者：Christopher G. Bruce, Jaffar M. Khan, Toby Rogers, Dursun Korel Yildirim, Andrea E. Jaimes, Felicia Seemann, Marcus Y. Chen, Kendall O’Brien, Daniel A. Herzka, William H. Schenke, Michael Eckhaus, Amanda Potersnak, Adrienne Campbell‐Washburn, Vasilis Babaliaros, Adam B. Greenbaum, Robert J. Lederman · 发表于：JACC Basic to Translational Science · 年份：2022 · DOI：10.1016/j.jacbts.2022.07.002 · 被引用次数：16 · 研究领域：Cardiac Structural Anomalies and Repair、Cardiac Valve Diseases and Treatments、Mechanical Circulatory Support Devices

MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a transcatheter ventricular remodeling procedure. A transvenous tension element is placed within the walls of the beating left ventricle and shortened to narrow chamber dimensions. MIRTH uses 2 new techniques: controlled intramyocardial guidewire navigation and EDEN (Electrocardiographic Radial Depth Navigation). MIRTH caused a sustained reduction in chamber dimensions in healthy swine. Midventricular implants approximated papillary muscles. MIRTH shortening improved myocardial contractility in cardiomyopathy in a dose-dependent manner up to a threshold beyond which additional shortening reduced performance. MIRTH may help treat dilated cardiomyopathy. Clinical investigation is warranted.