Combined phototherapy with metabolic reprogramming-targeted albumin nanoparticles for treating breast cancer

作者：Xuan Thien Le, Junyeong Lee, Nguyen Thi Nguyen, Woo Tak Lee, Eun Seong Lee, Kyung Taek Oh, Han‐Gon Choi, Beom Soo Shin, Yu Seok Youn · 发表于：Biomaterials Science · 年份：2022 · DOI：10.1039/d2bm01281b · 被引用次数：20 · 研究领域：Cancer, Hypoxia, and Metabolism、Nanoplatforms for cancer theranostics、Photodynamic Therapy Research Studies

, which was 21 times smaller than that of the untreated group and was much lower than those of other single treatments after 21 days. Additionally, almost no systemic undesired toxicity was detected during the observation period. We believe that the concept of LCIR as presented here offers a potential platform to overcome the resistance to conventional therapies by the incorporation with the energy metabolism inhibition approach.