Unruptured brain arteriovenous malformations causing seizures localize to one common brain network

作者：Shaozhi Zhao, Yu‐Xin Zhao, Xiao‐Hua Liao, Ran Huo, Hao Li, Yuming Jiao, Jiancong Weng, Jie Wang, Bing Liu, Yong Cao · 发表于：Journal of Neuroscience Research · 年份：2022 · DOI：10.1002/jnr.25142 · 被引用次数：8 · 研究领域：Functional Brain Connectivity Studies、Advanced Memory and Neural Computing、Advanced Neuroimaging Techniques and Applications

Seizures are a frequent symptom of unruptured brain arteriovenous malformations (bAVMs). However, the brain regions responsible for these seizures remain unclear. To identify the brain regions causally involved in bAVM-related seizures, we retrospectively reviewed 220 patients with unruptured bAVMs. Using voxel-based lesion-symptom mapping (VLSM) analyses, we tested whether individual brain regions were associated with unruptured bAVM-related seizures. The result revealed that unruptured bAVMs causing seizures are anatomically heterogeneous at the voxel level. Subsequently, lesion network mapping (LNM) analyses was performed to determine whether bAVMs causing seizures belonged to a distributed brain network. LNM analyses indicated that these lesions were located in a functional network characterized by connectivity to the left caudate and precuneus. Moreover, the discrimination performance of the identified seizure network was evaluated in discovery set by calculating the individualized network damage score and was tested in validation set. Based on the calculated network damage scores, patients were divided into low-, medium-, and high-risk groups. The prevalence of seizures significantly differed among the three risk categories in both discovery (p = .003) and validation set (p = .004). Finally, we calculated the percentage of voxels in the canonical resting-state networks that overlapped with the seizure-susceptible brain regions to investigate the involvement of resting-s...