Disrupted local functional connectivity in schizophrenia: An updated and extended meta-analysis

作者：Mengjing Cai, Rui Wang, Mengge Liu, Xiaotong Du, Kaizhong Xue, Yuan Ji, Zirui Wang, Yijing Zhang, Lining Guo, Wen Qin, Wenshuang Zhu, Jilian Fu, Feng Liu · 发表于：Schizophrenia · 年份：2022 · DOI：10.1038/s41537-022-00311-2 · 被引用次数：59 · 研究领域：Functional Brain Connectivity Studies、Advanced Neuroimaging Techniques and Applications、Advanced MRI Techniques and Applications

Neuroimaging studies have shown that schizophrenia is associated with disruption of resting-state local functional connectivity. However, these findings vary considerably, which hampers our understanding of the underlying pathophysiological mechanisms of schizophrenia. Here, we performed an updated and extended meta-analysis to identify the most consistent changes of local functional connectivity measured by regional homogeneity (ReHo) in schizophrenia. Specifically, a systematic search of ReHo studies in patients with schizophrenia in PubMed, Embase, and Web of Science identified 18 studies (20 datasets), including 652 patients and 596 healthy controls. In addition, we included three whole-brain statistical maps of ReHo differences calculated based on independent datasets (163 patients and 194 controls). A voxel-wise meta-analysis was then conducted to investigate ReHo alterations and their relationship with clinical characteristics using the newly developed seed-based d mapping with permutation of subject images (SDM-PSI) meta-analytic approach. Compared with healthy controls, patients with schizophrenia showed significantly higher ReHo in the bilateral medial superior frontal gyrus, while lower ReHo in the bilateral postcentral gyrus, right precentral gyrus, and right middle occipital gyrus. The following sensitivity analyses including jackknife analysis, subgroup analysis, heterogeneity test, and publication bias test demonstrated that our results were robust and highly r...