Relationship between heart rate variability and cognitive function in patients with enlarged perivascular space

作者：Dongyang Zhou, Lu Chang, Chunhe Su, Yuechen Liu, Jing Chen, Feng Zhang, Hongying Bai, Qianqian Li · 发表于：Frontiers in Aging Neuroscience · 年份：2022 · DOI：10.3389/fnagi.2022.1031031 · 被引用次数：2 · 研究领域：Cerebrospinal fluid and hydrocephalus、Vestibular and auditory disorders、Fetal and Pediatric Neurological Disorders

Objective To explore the relationship between heart rate variability (HRV), the brain distribution of enlarged perivascular space (EPVS), and cognitive impairment in patients with EPVS. Materials and methods The clinical and imaging data of 199 patients with EPVS were retrospectively analyzed. EPVS load in the basal ganglia (BG) and centrum semiovale (CS) regions were assessed using the Potter’s method. Cognitive function was evaluated using the Montreal Cognitive Assessment Scale. A logistic regression model was used to analyze the relationship between HRV, the brain distribution of EPVS and cognitive function in patients with EPVS. A receiver operating characteristic curve was used to assess the predictive value of HRV for cognitive function in patients with EPVS. Results Of the 199 patients, 27 and 42 presented with severe BG-EPVS and cognitive impairment, respectively. Significant differences were observed in the root mean square of successive differences of normal-normal (NN) intervals for period of interest (rMSSD), the percentage of adjacent NN intervals greater than 50 ms (PNN50), and the ratio of low-frequency power (LF) to high-frequency power (HF) between the mild and severe BG-EPVS groups ( P < 0.05). Patients who presented with and without cognitive impairment differed significantly in the standard deviation of NN intervals (SDNN), rMSSD, PNN50, total power, LF, and LF/HF ( P < 0.05). rMSSD (odds ratio [OR] 0.871, 95% confidence interval [CI] 0.768–...