Structural characterization of a polysaccharide from Abelmoschus esculentus L. Moench (okra) and its hypoglycemic effect and mechanism on type 2 diabetes mellitus

作者：Xue-Qing Geng, Lichao Pan, Hui-Qing Sun, Yuanyuan Ren, Zhen‐Yuan Zhu · 发表于：Food & Function · 年份：2022 · DOI：10.1039/d2fo02575b · 被引用次数：32 · 研究领域：Polysaccharides Composition and Applications、Polysaccharides and Plant Cell Walls、Natural Antidiabetic Agents Studies

in a molar ratio of 2.42 : 3.36 : 6.46 : 13.31 : 3.12 : 1, respectively. The hypoglycemic effect and mechanism of AeP-P-1 on type 2 diabetes mellitus were also explored. Firstly, AeP-P-1 can reduce blood lipids and liver and kidney damage caused by T2DM. Finally, AeP-P-1 induces the phosphorylation of GSK3β, maintains the activity of glycogen synthase (GCS), and promotes glycogen synthesis by regulating the expression of insulin/PI3K/Akt pathway proteins. These results indicated that AeP-P-1 could be developed as a potential ingredient in immunostimulatory agents.