Lactobacillus rhamnosus GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota

作者：Yu Gu, Xiali Qin, Guoqiong Zhou, Chen Wang, Chenlu Mu, Xiang Liu, Weilong Zhong, Xin Xu, Bangmao Wang, Kui Jiang, Jinghua Liu, Hailong Cao · 发表于：Food & Function · 年份：2022 · DOI：10.1039/d2fo01900k · 被引用次数：58 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Helicobacter pylori-related gastroenterology studies

XlVa in the LGGs group, which have been reported to be involved in regulating gut motility and the intestinal barrier, and alleviating bowel dysfunction. Interestingly, gut dysbiosis was present in the tegaserod group. It is noteworthy that the fecal microbiota transplanted from LGGs-treated mice significantly improved the gut dysmotility in a constipation mouse model. Our results suggested that LGGs could upregulate 5-HT4R to promote MUC2 production, as well as modulate the gut microbiota, thus improving the defecation function in mice. This finding might provide evidence for the application of diet supplementary LGG in relieving gastrointestinal motility disorders.