Effects of essential oil extracted from Artemisia argyi leaf on lipid metabolism and gut microbiota in high-fat diet-fed mice

作者：Kaijun Wang, Jie Ma, Yunxia Li, Qi Han, Zhangzheng Yin, Miao Zhou, Minyi Luo, Jiayi Chen, Siting Xia · 发表于：Frontiers in Nutrition · 年份：2022 · DOI：10.3389/fnut.2022.1024722 · 被引用次数：64 · 研究领域：Gut microbiota and health、Ginger and Zingiberaceae research、Metabolomics and Mass Spectrometry Studies

Artemisia argyi leaf is a well-known species in traditional Chinese medicine, and its essential oil (AAEO) has been identified to exert various physiological activities. The aim of this study was to investigate the effects of AAEO on lipid metabolism and the potential microbial role in high-fat diet (HFD)-fed mice. A total of 50 male mice were assigned to five groups for feeding with a control diet (Con), a high-fat diet (HFD), and the HFD plus the low (LEO), medium (MEO), and high (HEO) doses of AAEO. The results demonstrated that dietary HFD markedly increased the body weight gain compared with the control mice ( p < 0.05), while mice in the HEO group showed a lower body weight compared to the HFD group ( p < 0.05). The weight of fatty tissues and serum lipid indexes (TBA, HDL, and LDL levels) were increased in response to dietary HFD, while there was no significant difference in AAEO-treated mice ( p < 0.05). The jejunal villus height was dramatically decreased in HFD-fed mice compared with the control mice, while HEO resulted in a dramatically higher villus height than that in the HFD group ( p < 0.05). Microbial α-diversity was not changed in this study, but β-diversity indicated that microbial compositions differed in control, HFD, and EO subjects. At the genus level, the relative abundance of Bacteroides was greater ( p < 0.05) in the feces of the Con group when compared to the HFD and EO groups. On the contrary, the abundance of Muri...