Construction of an Axially Chiral Fluorene Nitrile-Based Framework via Benzannulation of Indene Diene with Benzoylacetonitrile

作者：Yi-Hang Deng, Lei Qin, Ran Li, Yan‐Bo Wang, Junyan Zhu, Ji‐Ya Fu, Chuan-Bao Zhang, Lili Zhao · 发表于：Organic Letters · 年份：2022 · DOI：10.1021/acs.orglett.2c03179 · 被引用次数：11 · 研究领域：Axial and Atropisomeric Chirality Synthesis、Molecular spectroscopy and chirality、Algebraic structures and combinatorial models

The methodology for the synthesis of fluorene-based atropisomers was developed via the strategy of aromatic ring formation. By this strategy, an efficient benzannulation of indene-based diene with benzoylacetonitrile divergently promoted by DABCO and a chiral organocatalyst was established, and various atropisomeric fluorene-based skeletons were generated in good yields, which not only provide a new strategy for the construction of atropisomeric biaryls but also offer a new member to the atropisomeric family.