Characterization and Function of Glycans on the Spike Proteins of SARS-CoV-2 Variants of Concern

作者：Luping Zheng, Ke Wang, Minghai Chen, Fujun Qin, Chuang Yan, Xian‐En Zhang · 发表于：Microbiology Spectrum · 年份：2022 · DOI：10.1128/spectrum.03120-22 · 被引用次数：17 · 研究领域：SARS-CoV-2 and COVID-19 Research、Bacteriophages and microbial interactions、Viral gastroenteritis research and epidemiology

gene affect the S protein glycan expression pattern in different variants. More importantly, we found that glycans were differentially expressed on the S protein of the Omicron variant, enabling different forms of receptor binding and neutralization resistance. This study improves our understanding of SARS-CoV-2 glycomics and glycobiology and provides novel therapeutic and preventive strategies for SARS-CoV-2 VOCs.