Engineering bio-inks for 3D bioprinting cell mechanical microenvironment

作者：Yanshen Yang, Yuanbo Jia, Qingzhen Yang, Feng Xu · 发表于：International Journal of Bioprinting · 年份：2022 · DOI：10.18063/ijb.v9i1.632 · 被引用次数：39 · 研究领域：Cellular Mechanics and Interactions、3D Printing in Biomedical Research、Bone Tissue Engineering Materials

Three-dimensional (3D) bioprinting has become a promising approach to construct­ing functional biomimetic tissues for tissue engineering and regenerative medicine. In 3D bioprinting, bio-inks are essential for the construction of cell microenviron­ment, thus affecting the biomimetic design and regenerative efficiency. Mechanical properties are one of the essential aspects of microenvironment, which can be char­acterized by matrix stiffness, viscoelasticity, topography, and dynamic mechanical stimulation. With the recent advances in functional biomaterials, various engineered bio-inks have realized the possibility of engineering cell mechanical microenviron­ment in vivo. In this review, we summarize the critical mechanical cues of cell micro­environments, review the engineered bio-inks while focusing on the selection princi­ples for constructing cell mechanical microenvironments, and discuss the challenges facing this field and the possible solutions for them.