Depicting the Implication of miR-378a in Cancers

作者：Yuelan Qin, Renba Liang, Pingan Lu, Lin Lai, Xiaodong Zhu · 发表于：Technology in Cancer Research & Treatment · 年份：2022 · DOI：10.1177/15330338221134385 · 被引用次数：11 · 研究领域：MicroRNA in disease regulation、Cancer-related molecular mechanisms research、Circular RNAs in diseases

gene. miR-378a is essential for tumorigenesis and is an independent prognostic biomarker for various malignant tumors. Aberrant expression of miR-378a affects several physiological and pathological processes, including proliferation, apoptosis, tumorigenesis, cancer invasion, metastasis, and therapeutic resistance. Interestingly, miR-378a has a dual functional role in either promoting or inhibiting tumorigenesis, independent of the cancer type. In this review, we comprehensively summarized the role and regulatory mechanisms of miR-378a in cancer development, hoping to provide a direction for its potential use in cancer therapy.