Assessment of Statin Treatment for Pulmonary Alveolar Proteinosis without Hypercholesterolemia: A 12‐Month Prospective, Longitudinal, and Observational Study

作者：Shenyun Shi, Xianhua Gui, Jingjing Ding, Shangwen Yang, Xiaoyan Xin, Kai‐Feng Xu, Yonglong Xiao · 发表于：BioMed Research International · 年份：2022 · DOI：10.1155/2022/1589660 · 被引用次数：19 · 研究领域：Neonatal Respiratory Health Research、Pulmonary Hypertension Research and Treatments、Medical Imaging and Pathology Studies

Background . Pulmonary alveolar proteinosis (PAP) is a rare disorder which is characterized by the accumulation of excessive surfactant lipids and proteins in alveolar macrophages and alveoli. Oral statin therapy has been reported to be a novel therapy for PAP with hypercholesterolemia. We aimed to evaluate the safety and efficacy of oral statin therapy for PAP without hypercholesterolemia. Methods . In a prospective real‐world observational study, 47 PAP patients without hypercholesterolemia were screened. Oral statin was initiated as therapy for these PAP patients with 12 months of follow‐up. Results . Forty PAP patients completed the study. 26 (65%) of 40 PAP patients responded to statin therapy according to the study criteria. Partial pressure of arterial oxygen (PaO2) and percentage of diffusion capacity predicted (DLCO%) significantly increased while disease severity score (DSS) and radiographic abnormalities decreased after 12 months of statin therapy (all p < 0.05). The factors associated with response were higher levels of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) antibody and baseline total cholesterol/high‐density lipoprotein cholesterol (TC/HDL) ( p = 0.015 and p = 0.035, respectively). The area under the receiver operating characteristic curve (AUROC) of dose of atorvastatin for predicting the response to statin therapy for PAP was 0.859 (95% CI: 0.738‐0.979, p < 0.001). The cutoff dose of atorvastatin was 67.5 mg daily with their correspond...