Orally Administered Platinum Nanomarkers for Urinary Monitoring of Inflammatory Bowel Disease

作者：Dongtao Zhou, Yi Yin, Zhenxing Zhu, Yanfeng Gao, Jingjing Yang, Yongchun Pan, Yujun Song · 发表于：ACS Nano · 年份：2022 · DOI：10.1021/acsnano.2c06705 · 被引用次数：51 · 研究领域：Pregnancy and Medication Impact、Nanocluster Synthesis and Applications、Advanced Nanomaterials in Catalysis

Inflammatory bowel disease (IBD) is a chronic relapsing autoimmune disease with rising incidence worldwide. There is an increasing desire for non-invasive diagnostic tools to enable simple and sensitive IBD monitoring. Here, we report an orally administered nanosensor which will dissociate into ultrasmall platinum nanoclusters (PtNCs) in IBD-related inflammatory microenvironments. By exploiting the enzyme-mimicking activity of PtNCs and the precise bandpass filterability of kidney, the released-PtNCs can be detected in a scalable urinary readout, such as fluorescence and volumetric bar-chart chip (V-Chip), for point-of-care (POC) analysis. Our results demonstrate that the nanosensors exhibit significant signal differences between IBD-model mice and healthy mice, which is more sensitive than clinical ELISA assay based on fecal calprotectin. Such a non-invasive diagnostic modality significantly assists in the personalized assessment of pharmacological and follow-up efficacy. We envision that this modular conception will promote the rapid diagnosis of diverse diseases by changing specific responsive components.