Synergistic Effect of the Combination of Deferoxamine and Fluconazole In Vitro and In Vivo against Fluconazole-Resistant Candida Spp.

作者：Lulu An, Jingwen Tan, Yuanyuan Wang, Siyu Liu, Yongyong Li, Lianjuan Yang · 发表于：Antimicrobial Agents and Chemotherapy · 年份：2022 · DOI：10.1128/aac.00725-22 · 被引用次数：15 · 研究领域：Antifungal resistance and susceptibility、Pneumocystis jirovecii pneumonia detection and treatment、Fungal Infections and Studies

The opportunistic fungal infections are an increasing threat to humans due to the increasing number of patients with immunodeficiency, in which the most popular fungal pathogen is Candida albicans . Fluconazole (FLC) is the common drug for treating C. albicans infections, but increasing drug resistance has limited its clinical use.