Genome-Wide Association Studies across Environmental and Genetic Contexts Reveal Complex Genetic Architecture of Symbiotic Extended Phenotypes

作者：Rebecca T. Batstone, Hanna Lindgren, Cassandra M. Allsup, Laura A. Goralka, Alex B. Riley, Michael A. Grillo, Amy Marshall‐Colón, Katy D. Heath · 发表于：mBio · 年份：2022 · DOI：10.1128/mbio.01823-22 · 被引用次数：19 · 研究领域：Legume Nitrogen Fixing Symbiosis、Nematode management and characterization studies、Insect symbiosis and bacterial influences

Given the rapid rise of research on how microbiomes can be harnessed to improve host health, understanding the contribution of microbial genetic variation to host phenotypic variation is pressing, and will better enable us to predict the evolution of (and select more precisely for) symbiotic extended phenotypes that impact host health. We uncover extensive context-dependency in both the identity and functions of symbiont loci that control host growth, which makes predicting the genes and pathways important for determining symbiotic outcomes under different conditions more challenging. Despite this context-dependency, we also resolve a core set of universal loci that are likely important in all or most environments, and thus, serve as excellent targets both for genetic engineering and future coevolutionary studies of symbiosis.