Combining Enzyme and Photoredox Catalysis for the Construction of 3-Aminoalkyl Chromones

作者：Jiayu Hu, Zongbo Xie, Juan Tang, Zhanggao Le, Zhiqiang Zhu · 发表于：The Journal of Organic Chemistry · 年份：2022 · DOI：10.1021/acs.joc.2c01977 · 被引用次数：26 · 研究领域：Synthesis of Organic Compounds、Radical Photochemical Reactions、Sulfur-Based Synthesis Techniques

Herein, we reported a practical and efficient strategy combining photoredox and enzyme catalysis for the construction of 3-aminoalkyl chromones from o -hydroxyaryl enaminones and N -arylglycine esters. A variety of 3-aminoalkyl chromones were synthesized with good yields under mild conditions in one pot. This synthetic protocol consists of sequential enzymatic hydrolysis and photoredox decarboxylation of N -arylglycine esters, oxidation of aminoalkyl radicals, Mannich reaction, and intramolecular nucleophilic cyclization, which affords a convenient pathway for the preparation of various 3-substituted chromones.