Metabolic signatures of immune cells in chronic kidney disease

作者：Jie Li, Yi Yang, Yanan Wang, Qing Li, Fan He · 发表于：Expert Reviews in Molecular Medicine · 年份：2022 · DOI：10.1017/erm.2022.35 · 被引用次数：34 · 研究领域：Immune Cell Function and Interaction、Diabetes and associated disorders、Immune cells in cancer

Immune cells play a key role in maintaining renal dynamic balance and dealing with renal injury. The physiological and pathological functions of immune cells are intricately connected to their metabolic characteristics. However, immunometabolism in chronic kidney disease (CKD) is not fully understood. Pathophysiologically, disruption of kidney immune cells homeostasis causes inflammation and tissue damage via triggering metabolic reprogramming. The diverse metabolic characteristics of immune cells at different stages of CKD are strongly associated with their different pathological effect. In this work, we reviewed the metabolic characteristics of immune cells (macrophages, natural killer cells, T cells, natural killer T cells and B cells) and several non-immune cells, as well as potential treatments targeting immunometabolism in CKD. We attempt to elaborate on the metabolic signatures of immune cells and their intimate correlation with non-immune cells in CKD.