Spatial transcriptome profiling of normal human liver

作者：Shizhe Yu, Haoren Wang, Lingpeng Yang, Yingxue Yan, Qiang Cai, Duo Ma, Long Jiang, Zehai Gao, Zhiyong Yu, Zongping Xia · 发表于：Scientific Data · 年份：2022 · DOI：10.1038/s41597-022-01676-w · 被引用次数：27 · 研究领域：Single-cell and spatial transcriptomics、Liver Disease Diagnosis and Treatment、Gene expression and cancer classification

The comprehensive study of the spatial-cellular anatomy of the human liver is critical to addressing the cellular origins of liver disease. Here we conducted spatial transcriptomics on normal human liver tissue sections, providing detailed information of liver zonation at the transcriptional level. We present 6581 high-quality spots from normal livers of two human donors. In this dataset, cells were mainly hepatocytes, and we classified them into four sub-groups. Collectively, these data provide a reliable reference for studies on spatial heterogeneity of liver lobules.