Proteins from Thermophilic Thermus thermophilus Often Do Not Fold Correctly in a Mesophilic Expression System Such as Escherichia coli

作者：Alibek Kruglikov, Yulong Wei, Xuhua Xia · 发表于：ACS Omega · 年份：2022 · DOI：10.1021/acsomega.2c04786 · 被引用次数：18 · 研究领域：Protein Structure and Dynamics、Enzyme Structure and Function、RNA and protein synthesis mechanisms

. Our results show unique directionality in misfolding when proteins in thermophiles are expressed in mesophiles. This indicates that extremophiles, such as thermophiles, require unique protein expression systems in protein folding studies.