A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer’s Disease Continuum

作者：Emma M. Coomans, Inge M.W. Verberk, Rik Ossenkoppele, Sander C.J. Verfaillie, Denise Visser, Mariam Gouda, Hayel Tuncel, Emma E. Wolters, Tessa Timmers, Albert D. Windhorst, Sandeep S.V. Golla, Philip Scheltens, Wiesje M. van, der Flier, Bart N.M. van Berckel, Charlotte E. Teunissen · 发表于：Journal of Nuclear Medicine · 年份：2022 · DOI：10.2967/jnumed.122.264279 · 被引用次数：65 · 研究领域：Dementia and Cognitive Impairment Research、Alzheimer's disease research and treatments、S100 Proteins and Annexins

Gitelman9s syndrome is a congenital renal tubular defect which affects the apical membrane of the distal convoluted tubule of the renal system. The syndrome is characterised by hypokalaemia, hypomagnesaemia, metabolic alkalosis and hypocalcuria. There are only a few cases describing the impact of Gitelman9s syndrome on pregnancy and the foetus. Although most pregnancies have favourable outcomes, fetal demise has been reported in the third trimester. We report the successful outcome of pregnancy in a patient with Gitelman9s syndrome who continued on amiloride in pregnancy to optimise potassium and magnesium levels and review the literature for pregnancy outcomes of this condition.