Phytochemical, antioxidant, enzyme inhibitory, thrombolytic, antibacterial, antiviral and in silico studies of Acacia jacquemontii leaves

作者：Maqsood Ahmed, Kashif-ur-Rehman Khan, Saeed Ahmad, Hanan Y. Aati, Asma E. Sherif, Mada F. Ashkan, Jehan Alrahimi, Ebtihal Abdullah Motwali, Muhammad Imran Tousif, Mohsin Abbas Khan, Musaddique Hussain, Muhammad Umair, Bilal Ahmad Ghalloo, Sameh A. Korma · 发表于：Arabian Journal of Chemistry · 年份：2022 · DOI：10.1016/j.arabjc.2022.104345 · 被引用次数：35 · 研究领域：Phytochemicals and Antioxidant Activities、Natural product bioactivities and synthesis、Plant biochemistry and biosynthesis

The main objective of this work was to gain insight into biological propensities, and bioactive phytochemicals of Acacia jacquemontii Benth, a wild plant providing medicinal components, as well as to establish a link between its phytochemical profile and biological activities. Phytochemical profiling revealed the presence of a higher amount of total phenolic (271.44 ± 4.41 mg GAE/g) and flavonoid contents (216.47 ± 5.82 mg QE/g) in methanolic extract (MEAJ), and as compared to n -hexane fraction (HEAJ) and stronger biological activities of MEAJ were possibly linked to the higher bioactive contents. The freshly collected plant leaves showed a strong antioxidant potential (total antioxidant capacity 1.03 ± 0.19 mmol TE/g), which was found even stronger in dried methanolic extract (TAC; 4.36 ± 1.12 mmol TE/g), moreover, MEAJ also showed strong antioxidant potential when investigated by different antioxidant assays (DPPH; 154.04 ± 2.47, ABTS; 122.36 ± 0.80, FRAP; 453.18 ± 5.9, CUPRAC; 1389.97 ± 5.32 mg TE/g). The MEAJ showed good tyrosinase inhibition activity (71.69 %), compared with 83 % inhibition by kojic acid. Ten major compounds identified by GC–MS were docked and eight legends showed lower binding energies (-6 to −7.8 kcal/mol) compared with kojic acid (-5.9 kcal/mol), which shows the possible role of these compounds in the anti-tyrosinase activity of the extract, and the ADMET analysis predicted the drug-likeness and safety profile of the studied compounds. The thrombolyt...