Sleep, short-term memory, and mood states of volunteers with increasing altitude

作者：Huanhuan Wang, Xueyan Li, Jianhua Li, Yinghui Gao, Weihua Li, Xinke Zhao, Ruoqing Wen, Jiming Han, Kaibing Chen, Lin Liu · 发表于：Frontiers in Psychiatry · 年份：2022 · DOI：10.3389/fpsyt.2022.952399 · 被引用次数：18 · 研究领域：High Altitude and Hypoxia、Sleep and related disorders、Sleep and Wakefulness Research

Purpose This study sought to identify the changes and potential association between sleep characteristics and short-term memory, and mood states among volunteers at different altitudes and times. Method A total of 26 healthy volunteers were recruited from the PLA General Hospital, and we conducted a longitudinal prospective survey for over 1 year from November 2019 to April 2021. First, we collected demographic data, sleep parameters by overnight polysomnography (PSG), short-term memory by digit span test, and mood states by completing a questionnaire with a brief profile of mood states among participants in the plain (53 m). Then, we continuously followed them up to collect data in the 3rd month at an altitude of 1,650 m (on the 3rd month of the 1-year survey period), the 3rd month at an altitude of 4,000 m (on the 6th month of the 1-year survey period), and the 9th month at an altitude of 4,000 m (on the 12th month of the 1-year survey period). Multiple linear regression analysis was used to construct models between sleep parameters and short-term memory, and mood states. Results The prevalence of sleep apnea syndrome (SAS) significantly increased with rising elevation ( P < 0.01). The apnea-hypopnea index (AHI), the mean apnea time (MAT), the longest apnea time (LAT), and the duration of time with SaO 2 < 90% (TSA90) were increased ( P < 0.05), and the mean pulse oxygen saturation (MSpO 2 ), the lowest pulse oxygen saturation (LSpO 2 ), and heart rate ...