Efficacy of twice-daily high-frequency repetitive transcranial magnetic stimulation on associative memory

作者：Qiang Hua, Yuanyuan Zhang, Qianqian Li, Xiaoran Gao, Rongrong Du, Yingru Wang, Qian Zhou, Ting Zhang, Jinmei Sun, Lei Zhang, Gong‐Jun Ji, Kai Wang · 发表于：Frontiers in Human Neuroscience · 年份：2022 · DOI：10.3389/fnhum.2022.973298 · 被引用次数：3 · 研究领域：Spatial Neglect and Hemispheric Dysfunction、Transcranial Magnetic Stimulation Studies、Neural and Behavioral Psychology Studies

Objectives Several studies have examined the effects of repetitive transcranial magnetic stimulation (rTMS) on associative memory (AM) but findings were inconsistent. Here, we aimed to test whether twice-daily rTMS could significantly improve AM. Methods In this single-blind, sham-controlled experiment, 40 participants were randomized to receive twice-daily sham or real rTMS sessions for five consecutive days (a total of 16,000 pulses). The stimulation target in left inferior parietal lobule (IPL) exhibiting peak functional connectivity to the left hippocampus was individually defined for each participant. Participants completed both a picture-cued word association task and Stroop test at baseline and 1 day after the final real or sham rTMS session. Effects of twice-daily rTMS on AM and Stroop test performance were compared using two-way repeated measures analysis of variance with main factors Group (real vs. sham) and Time (baseline vs. post-rTMS). Results There was a significant Group × Time interaction effect. AM score was significantly enhanced in the twice-daily real group after rTMS, but this difference could not survive the post hoc analysis after multiple comparison correction. Further, AM improvement in the twice-daily real group was not superior to a previously reported once-daily rTMS group receiving 8,000 pulses. Then, we combined the twice- and once-daily real groups, and found a significant Group × Time interaction effect. Post hoc analysis indicated that the AM...