Remarkable contribution of particulate matter-induced macrophage ferroptosis to the pathology of pulmonary fibrosis

作者：Guangzhe Zheng, Shihao Bi, Jiayu Ren, Sijin Liu, Bin Shi · 发表于：Journal of Endocrinological Science · 年份：2022 · DOI：10.29245/2767-5157/2022/2.1124 · 被引用次数：4 · 研究领域：Occupational and environmental lung diseases、Ferroptosis and cancer prognosis、Air Quality and Health Impacts

Occupational exposure to particulate matter (PM) induced pulmonary fibrosis has aroused broad public concern. Pulmonary interstitial fibrosis is a central pathologic process of pneumoconiosis. Meanwhile, ferroptosis is a newly defined iron-dependent programmed cell death (PCD) that features increased intracellular labile iron and lethal accumulation of lipid peroxidation. Ferroptosis has been found to involve particulate-induced cytotoxicity. Recent studies have suggested that ferroptosis is closely associated with the occurrence and progression of pulmonary fibrosis. Here, we present a mini review to summarize the main mechanisms responsible for PM-induced pulmonary fibrosis via inducing macrophage ferroptosis to provide new insights into basic and clinical research of pulmonary fibrosis.