Visible-Light-Induced Metal-Free Decarboxylative Perfluoroalkylation of Aryl Acrylic Acids

作者：Mo Yu, Kaikai Niu, Ziwen Wang, Yuxiu Liu, Qingmin Wang · 发表于：Organic Letters · 年份：2022 · DOI：10.1021/acs.orglett.2c03088 · 被引用次数：20 · 研究领域：Fluorine in Organic Chemistry、Radical Photochemical Reactions、Sulfur-Based Synthesis Techniques

Perfluoroalkylation is important for late-stage modification of biologically active molecules. Herein, we report a protocol for visible-light-induced perfluoroalkylation reactions of aryl acrylic acids. These reactions, which use perfluoroalkyl iodides as radical precursors and inexpensive eosin Y as a photocatalyst, proceed in a decarboxylative manner. The easy accessibility of perfluoroalkyl iodides and the broad substrate scope, mild conditions, and metal-free catalyst make this protocol applicable for the transformation of inexpensive raw materials to high-value chemicals.