Research Progress on Bacterial Membrane Vesicles and Antibiotic Resistance

作者：Xiaofei Liu, Jinyang Xiao, Shuming Wang, Jinxia Zhou, Jiale Qin, Zhibo Jia, Yanfeng Wang, Zhigang Wang, Yongmin Zhang, Huifang Hao · 发表于：International Journal of Molecular Sciences · 年份：2022 · DOI：10.3390/ijms231911553 · 被引用次数：31 · 研究领域：Bacterial Infections and Vaccines、Pneumonia and Respiratory Infections、Antibiotic Resistance in Bacteria

As a result of antibiotic overuse, bacterial antibiotic resistance has become a severe threat to worldwide public health. The development of more effective antimicrobial therapies and alternative antibiotic strategies is urgently required. The role played by bacterial membrane vesicles (BMVs) in antibiotic resistance has become a current focus of research. BMVs are nanoparticles derived from the membrane components of Gram-negative and Gram-positive bacteria and contain diverse components originating from the cell envelope and cytoplasm. Antibiotic stress stimulates the secretion of BMVs. BMVs promote and mediate antibiotic resistance by multiple mechanisms. BMVs have been investigated as conceptually new antibiotics and drug-delivery vehicles. In this article, we outline the research related to BMVs and antibiotic resistance as a reference for the intentional use of BMVs to combat antibiotic resistance.