Anoikis-Associated Lung Cancer Metastasis: Mechanisms and Therapies

作者：Jing Wang, Zhijie Luo, Lizhu Lin, Xinbing Sui, Lili Yu, Cong Xu, Ruonan Zhang, Ziming Zhao, Qianru Zhu, Bo An, Qiao Wang, Bi Chen, Elaine Lai‐Han Leung, Qibiao Wu · 发表于：Cancers · 年份：2022 · DOI：10.3390/cancers14194791 · 被引用次数：130 · 研究领域：Signaling Pathways in Disease、Bioactive Compounds and Antitumor Agents、Berberine and alkaloids research

Tumor metastasis occurs in lung cancer, resulting in tumor progression and therapy failure. Anoikis is a mechanism of apoptosis that combats tumor metastasis; it inhibits the escape of tumor cells from the native extracellular matrix to other organs. Deciphering the regulators and mechanisms of anoikis in cancer metastasis is urgently needed to treat lung cancer. Several natural and synthetic products exhibit the pro-anoikis potential in lung cancer cells and in vivo models. These products include artonin E, imperatorin, oroxylin A, lupalbigenin, sulforaphane, renieramycin M, avicequinone B, and carbenoxolone. This review summarizes the current understanding of the molecular mechanisms of anoikis regulation and relevant regulators involved in lung cancer metastasis and discusses the therapeutic potential of targeting anoikis in the treatment of lung cancer metastasis.