Enantioselective C2–H Alkylation of Pyridines with 1,3-Dienes via Ni–Al Bimetallic Catalysis

作者：Jiang‐Fei Li, Deng Pan, Hao-Rui Wang, Tao Zhang, Yi Li, Genping Huang, Mengchun Ye · 发表于：Journal of the American Chemical Society · 年份：2022 · DOI：10.1021/jacs.2c09306 · 被引用次数：87 · 研究领域：Catalytic C–H Functionalization Methods、Asymmetric Hydrogenation and Catalysis、Asymmetric Synthesis and Catalysis

A chiral phosphine oxide-ligated Ni-Al bimetallic catalyst was used to realize an enantioselective C2-H alkylation of pyridines without the need of a C2-block. A wide range of pyridines, including unsubstituted pyridine, C3, C4, and C2-substituted pyridines, and even complex pyridine-containing bioactive molecules are well compatible with the reaction, providing up to 81% yield and up to 97% ee.