Effect of transcranial magnetic stimulation in combination with citalopram on patients with post-stroke depression

作者：Zhen Zhu, Hao-Xuan Zhu, Jing Shao-wei, Xia-Zhen Li, Xiaoyan Yang, Tu-Nan Luo, Shuai Ye, Xiao-Chun Ouyang, Weiwei Song · 发表于：Frontiers in Human Neuroscience · 年份：2022 · DOI：10.3389/fnhum.2022.962231 · 被引用次数：10 · 研究领域：Spatial Neglect and Hemispheric Dysfunction、Stroke Rehabilitation and Recovery、Transcranial Magnetic Stimulation Studies

Background Amelioration of depression in patients with post-stroke depression (PSD) remains challenging. Objective The primary vision was to explore the effect of transcranial magnetic stimulation (TMS) in combination with citalopram on patients with PSD. Methods One hundred eligible patients who were diagnosed with PSD were recruited and randomly assigned to the control group ( n = 50) or the TMS group ( n = 50). The controls were given citalopram (10 mg/d for consecutive 8 weeks), while, in addition to citalopram, patients in the TMS group were also given TMS at 5 Hz once a workday for 8 weeks. The primary outcome was patient depression status as reflected by 17-item Hamilton Rating Scale for Depression (HAMD-17) score, and the secondary outcome was patient neuropsychological score determined by Mini-Mental State Examination (MMSE) and Wisconsin Card Sorting Test (WCST). Results Patients treated with TMS in combination with citalopram had a drastic decrease in HAMD-17 score during treatment. Bigger changes in HAMD-17 score between baseline and 2 weeks as well as between baseline and 8 weeks in the TMS group were observed ( P < 0.01). Patients in both groups had increased MMSE scores after treatment. Data of WCST revealed patients with TMS treatment completed more categories ( P < 0.01) and had a lower RPP in comparison to patients in the control group ( P < 0.0001). Additionally, TMS in combination with citalopram strikingly improved patients' MMSE scor...