Bacterial Transcription Factors Bind to Coding Regions and Regulate Internal Cryptic Promoters

作者：Canfeng Hua, Jiadai Huang, Tingting Wang, Yue Sun, Jingui Liu, Linfeng Huang, Xin Deng · 发表于：mBio · 年份：2022 · DOI：10.1128/mbio.01643-22 · 被引用次数：32 · 研究领域：Bacterial Genetics and Biotechnology、Genomics and Phylogenetic Studies、RNA and protein synthesis mechanisms

Although bacterial TFs regulate transcription by binding to specific sequences at the promoter region, little is known about the mechanisms and functions of TFs binding within the CDS. In this study, we show that bacterial TFs have same binding pattern in both CDS and promoter regions, and we reveal three regulatory mechanisms of CDS-bound TF that together demonstrate the complexity of the regulatory mechanisms of bacterial TFs and the wide spread of internal cryptic promoters in CDS.