Interactions of Autophagy and the Immune System in Health and Diseases

作者：Aarti Pant, Xiaomin Yao, Aude Lavedrine, Christophe Viret, Jacob Dockterman, Swati Chauhan, Chong-Shan Shi, Ravi Manjithaya, Ken Cadwell, Thomas A. Kufer, John H. Kehrl, Jörn Coers, L. David Sibley, Mathias Faure, Gregory A. Taylor, Santosh Chauhan · 发表于：Autophagy Reports · 年份：2022 · DOI：10.1080/27694127.2022.2119743 · 被引用次数：24 · 研究领域：Autophagy in Disease and Therapy、Calcium signaling and nucleotide metabolism、Extracellular vesicles in disease

Autophagy is a highly conserved process that utilizes lysosomes to selectively degrade a variety of intracellular cargo, thus providing quality control over cellular components and maintaining cellular regulatory functions. Autophagy is triggered by multiple stimuli ranging from nutrient starvation to microbial infection. Autophagy extensively shapes and modulates the inflammatory response, the concerted action of immune cells, and secreted mediators aimed to eradicate a microbial infection or to heal sterile tissue damage. Here, we first review how autophagy affects innate immune signaling, cell-autonomous immune defense, and adaptive immunity. Then, we discuss the role of non-canonical autophagy in microbial infections and inflammation. Finally, we review how crosstalk between autophagy and inflammation influences infectious, metabolic, and autoimmune disorders.