Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptions

作者：Karine Dubé, Harsh Agarwal, William B. Carter, Lynda Dee, Jeff Taylor, Christopher Roebuck, Beth Peterson, Hursch Patel, Samuel Ndukwe, Kenneth Lynn, Linden Lalley-Chareczko, Emily Hiserodt, Su Kyung Kim, Daniel I. S. Rosenbloom, Brad R. Evans, Melanie Anderson, Daria J. Hazuda, Kevin P. Bateman, Bonnie J. Howell, Livio Azzoni, Karam Mounzer, Pablo Tebas, Luis J. Montaner · 发表于：HIV Research & Clinical Practice · 年份：2022 · DOI：10.1080/25787489.2022.2103582 · 被引用次数：18 · 研究领域：HIV/AIDS Research and Interventions、HIV Research and Treatment、HIV, Drug Use, Sexual Risk

Background: HIV cure-directed clinical trials using analytical treatment interruptions (ATIs) require participants to adhere to frequent monitoring visits for viral load tests. Novel viral load monitoring strategies are needed to decrease participant burden during ATIs.Objective: To examine acceptability of a novel home-based blood collection device for viral load testing in the context of two ongoing ATI trials in Philadelphia, PA, United States.Methods: From January 2021 to February 2022, participants completed three in-depth interviews via teleconference during their participation in an ATI: (1) within two weeks of enrollment in the device study, (2) approximately four weeks after beginning to use the device, and (3) within two weeks of the end of the ATI when ART was re-initiated. We used conventional content analysis to analyze the data.Results: We recruited 17 participants: 15 were cisgender males, 1 cisgender female, and 1 transgender woman. We observed an overall 87% success rate in drawing blood with the device from home collection and found overall high acceptance of the device. A mean of 91.5 devices per participant were used for home-based blood collection. Most PWH viewed the device as relatively convenient, painless, easy to use, and a simple solution to frequent blood draws. The main challenge encountered was the inability to completely fill up devices with blood in some cases. Most participants reported positive experiences with mailing blood samples and could...