A possible etiological role for ascorbate in calculi formation.

作者：Ainsley H. Chalmers, David M. Cowley, J M Brown · 发表于：Clinical Chemistry · 年份：1986 · DOI：10.1093/clinchem/32.2.333 · 被引用次数：71 · 研究领域：Kidney Stones and Urolithiasis Treatments

Studies of recurrent stone formers indicated that they have significantly increased urinary oxalate and decreased ascorbate excretions. Results of oral and intravenous administration of ascorbate indicate an enhanced production of oxalate from ascorbate in recurrent calcium stone formers as compared with normal persons and that most of this oxalate is generated in the gut.