Th17 cells in primary Sjögren’s syndrome negatively correlate with increased Roseburia and Coprococcus

作者：Xiaohong Xin, Qian Wang, Jianbo Qing, Wenzhu Song, Yanni Gui, Xiaofeng Li, Yafeng Li · 发表于：Frontiers in Immunology · 年份：2022 · DOI：10.3389/fimmu.2022.974648 · 被引用次数：48 · 研究领域：Salivary Gland Disorders and Functions、Gut microbiota and health、Dermatology and Skin Diseases

Background Dysbiosis of the gut microbiota is closely related to chronic systemic inflammation and autoimmunity, playing an essential role in the pathogenesis of primary Sjögren’s syndrome (pSS). Abnormalities in the proportions of blood T lymphocyte subtype, that is Th17/Treg, were detected in pSS patients. We aimed to determine the associations between gut microbiota and Th17/Treg in pSS. Method 98 pSS patients and 105 healthy controls (NC) were enrolled between Dec 1, 2018, and Aug 31, 2019. The baseline information and clinical parameters on pSS patients and healthy controls were collected. 16S rRNA sequencing was performed to characterize the gut microbiome and identify gut microbes that are differentially abundant between patients and healthy controls. Lastly, associations between relative abundances of specific bacterial taxa in the gut and clinical outcome parameters were evaluated. Results Patients with pSS show decreased gut microbial diversity and richness, decreased abundance of butyrate producing bacteria, such as Roseburia and Coprococcus , and increased abundance of other taxa, such as Eubacterium rectale and Roseburia inulinivorans . These bacteria are enriched with functions related to glycolytic and lipogenic, energy, substance, galactose, pentose metabolism pathways and glucuronate interconversions, decreased with functions related to peptidoglycan biosynthesis, pyrimidine metabolism pathways. An integrative analysis identified pSS-related specific bacteria...