Research progress of cartilage lubrication and biomimetic cartilage lubrication materials

作者：Haoming An, Yubo Liu, Jiafeng Yi, Hongbin Xie, Chao Li, Xing Wang, Wei Chai · 发表于：Frontiers in Bioengineering and Biotechnology · 年份：2022 · DOI：10.3389/fbioe.2022.1012653 · 被引用次数：43 · 研究领域：Osteoarthritis Treatment and Mechanisms、Lubricants and Their Additives、Total Knee Arthroplasty Outcomes

Human joints move thousands of times a day. The articular cartilage plays a vital role in joints' protection. If there is dysfunction in cartilage lubrication, cartilage cannot maintain its normal function. Eventually, the dysfunction may bring about osteoarthritis (OA). Extensive researches have shown that fluid film lubrication, boundary lubrication, and hydration lubrication are three discovered lubrication models at cartilage surface, and analyzing and simulating the mechanism of cartilage lubrication are fundamental to the treatment of OA. This essay concludes recent researches on the progress of cartilage lubrication and biomimetic cartilage, revealing the pathophysiology of cartilage lubrication and updating bio-inspired cartilage lubrication applications.