Effects of mechanical loading on the degradability and mechanical properties of the nanocalcium-deficient hydroxyapatite–multi(amino acid) copolymer composite membrane tube for guided bone regeneration

作者：H Duan, Yang HS, Youfu Xiong, Bangqin Zhang, Chonghong Ren, Min Liu, Zhang WL, Yan YG, Huijun Li, Pei FX, Tu CQ · 发表于：DOAJ (DOAJ: Directory of Open Access Journals) · 年份：2013 · 研究领域：Bone Tissue Engineering Materials、Dental Implant Techniques and Outcomes、Electrospun Nanofibers in Biomedical Applications

Hong Duan,1 Hongsheng Yang,1 Yan Xiong,1 Bin Zhang,1 Cheng Ren,1 Li Min,1 Wenli Zhang,1 Yonggang Yan,2 Hong Li,2 Fuxing Pei,1 Chongqi Tu11Department of Orthopedics, 2School of Physical Science and Technology, Sichuan University, Chengdu, People's Republic of ChinaBackground and methods: Guided bone regeneration (GBR) is a new treatment for bone defects, and the property of membrane is critical to the success of GBR. This study focuses on a novel membrane tube for GBR, which was prepared by a nanocalcium-deficient hydroxyapatite–multi(amino acid) copolymer (n-CDHA-MAC) composite. The biomechanical strength and degradability of this membrane tube under mechanical loading after immersion in phosphate-buffered solution were investigated to evaluate the effects of mechanical loading on the membrane tube. The membrane-tube group with no mechanical loading and femora bone were used as controls.Results: The compressive strength and bending strength of n-CDHA-MAC membrane tubes were 66.4 ± 10.2 MPa and 840.7 ± 12.1 MPa, which were lower than those of the goats’ femoral bones (69.0 ± 5.5 MPa and 900.2 ± 17.3 MPa), but there were no significant (P > 0.05) differences. In the in vitro degradability experiment, all membrane tubes were degradable and showed a surface-erosion degradation model. The PH of solution fluctuated from 7.2 to 7.5. The weight and mechanical strength of loaded tubes decreased more quickly than nonloaded ones, with signific...