Association of cortical thickness and cognition with schizophrenia treatment resistance

作者：Fengmei Fan, Junchao Huang, Shuping Tan, Zhiren Wang, Yanli Li, Song Chen, Hui Li, Stephanie Hare, Xiaoming Du, Fude Yang, Baopeng Tian, Peter Kochunov, Yunlong Tan, L. Elliot Hong · 发表于：Psychiatry and Clinical Neurosciences · 年份：2022 · DOI：10.1111/pcn.13486 · 被引用次数：22 · 研究领域：Schizophrenia research and treatment、Functional Brain Connectivity Studies、Neural and Behavioral Psychology Studies

AIM: Approximately a third of patients with schizophrenia fail to adequately respond to antipsychotic medications, a condition known as treatment resistance (TR). We aimed to assess cognitive and cortical thickness deficits and their relationship to TR in schizophrenia. METHOD: We recruited patients with schizophrenia (n = 127), including patients at treatment initiation (n = 45), treatment-responsive patients (n = 40) and TR patients (n = 42), and healthy controls (n = 83). Clinical symptoms, neurocognitive function, and structural images were assessed. We performed group comparisons, and explored association of cortical thickness and cognition with TR. RESULTS: The TR patients showed significantly more severe clinical symptoms and cognitive impairment relative to the treatment-responsive group. Compared to healthy controls, 56 of 68 brain regions showed significantly reduced cortical thickness in patients with schizophrenia. Reductions in five regions were significantly associated with TR (reduction in TR relative to treatment-responsive patients), i.e. in the right caudal middle frontal gyrus, superior frontal cortex, fusiform gyrus, pars opercularis of the inferior frontal cortex, and supramarginal cortex. Cognition deficits were also significantly correlated with cortical thickness in these five regions in patients with schizophrenia. Cortical thickness of the right caudal middle frontal gyrus, superior frontal cortex and pars opercularis of the inferior frontal cortex a...