Microbiome ethics, guiding principles for microbiome research, use and knowledge management

作者：Lene Lange, Gabriele Berg, Tomislav Cernava, Marie‐Christine Champomier‐Vergès, Trevor C. Charles, Luca Cocolin, Paul D. Cotter, Kathleen D’hondt, Tanja Kostić, Emmanuelle Maguin, Thulani P. Makhalanyane, Annelein Meisner, Matthew J. Ryan, George Seghal Kiran, Rafael Soares de Souza, Yolanda Sanz, Michael Schloter, Hauke Smidt, Steven A. Wakelin, Angela Sessitsch · 发表于：Environmental Microbiome · 年份：2022 · DOI：10.1186/s40793-022-00444-y · 被引用次数：54 · 研究领域：Gut microbiota and health、Ethics in Clinical Research、Zoonotic diseases and public health

The overarching biological impact of microbiomes on their hosts, and more generally their environment, reflects the co-evolution of a mutualistic symbiosis, generating fitness for both. Knowledge of microbiomes, their systemic role, interactions, and impact grows exponentially. When a research field of importance for planetary health evolves so rapidly, it is essential to consider it from an ethical holistic perspective. However, to date, the topic of microbiome ethics has received relatively little attention considering its importance. Here, ethical analysis of microbiome research, innovation, use, and potential impact is structured around the four cornerstone principles of ethics: Do Good; Don't Harm; Respect; Act Justly. This simple, but not simplistic approach allows ethical issues to be communicative and operational. The essence of the paper is captured in a set of eleven microbiome ethics recommendations, e.g., proposing gut microbiome status as common global heritage, similar to the internationally agreed status of major food crops.