Improved rapid diagnostic tests to detect syphilis and yaws: a systematic review and meta-analysis

作者：Ying Zhang, Su Mei Goh, Maeve B. Mello, Rachel Baggaley, Teodora Wi, Cheryl Johnson, Kingsley Asiedu, Michael Marks, Minh D. Pham, Christopher K. Fairley, Eric P. F. Chow, Oriol Mitjà, Igor Toskin, Ronald C. Ballard, Jason J. Ong · 发表于：Sexually Transmitted Infections · 年份：2022 · DOI：10.1136/sextrans-2022-055546 · 被引用次数：16 · 研究领域：Syphilis Diagnosis and Treatment、Reproductive tract infections research、Blood disorders and treatments

Background Current rapid tests for syphilis and yaws can detect treponemal and non-treponemal antibodies. We aimed to critically appraise the literature for rapid diagnostic tests (RDTs) which can better distinguish an active infection of syphilis or yaws. Methods We conducted a systematic review and meta-analysis, searching five databases between January 2010 and October 2021 (with an update in July 2022). A generalised linear mixed model was used to conduct a bivariate meta-analysis for the pooled sensitivity and specificity. Heterogeneity was assessed using the I 2 statistic. We used the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) to assess the risk of bias and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) to evaluate the certainty of evidence. Results We included 17 studies for meta-analyses. For syphilis, the pooled sensitivity and specificity of the treponemal component were 0.93 (95% CI: 0.86 to 0.97) and 0.98 (95% CI: 0.96 to 0.99), respectively. For the non-treponemal component, the pooled sensitivity and specificity were 0.90 (95% CI: 0.82 to 0.95) and 0.97 (95% CI: 0.92 to 0.99), respectively. For yaws, the pooled sensitivity and specificity of the treponemal component were 0.86 (95% CI: 0.66 to 0.95) and 0.97 (95% CI: 0.94 to 0.99), respectively. For the non-treponemal component, the pooled sensitivity and specificity were 0.80 (95% CI: 0.55 to 0.93) and 0.96 (95% CI: 0.92 to 0.98), respectively. Conclusions RDTs that c...