Targeted metabolomics combined with network pharmacology to reveal the protective role of luteolin in pulmonary arterial hypertension

作者：Kexin Song, Qingya Duan, Jiping Ren, Jie Yi, Hong Yu, Haixia Che, Chunjuan Yang, Xiaotong Wang, Qian Li · 发表于：Food & Function · 年份：2022 · DOI：10.1039/d2fo01424f · 被引用次数：25 · 研究领域：Pulmonary Hypertension Research and Treatments、Eicosanoids and Hypertension Pharmacology、Metabolomics and Mass Spectrometry Studies

-acetyl-L-ornithine, butane diacid, ornithine, glutamic acid metabolites in amino acid and TCA pathways. However, treatment with luteolin recovered the LTB4, PGE2, PGD2, 12-HETE, 15-HETE, PGF2α and 8-iso-PGF2α levels close to normal. Meanwhile, we showed that luteolin also downregulated the gene and protein levels of COX 1, 5-LOX, 12-LOX, and 15-LOX in the arachidonic acid pathway. Collectively, this work highlighted the metabolic mechanism of luteolin-protected PAH and showed that luteolin would hold great potential in PAH prevention.